Treatment with Botox: what is it and how is it done?

Botox is a substance that appeared relatively late in medicine and its entry into aesthetic medicine is even more recent. But it has since revolutionized this field, establishing itself as one of the most used substances in various treatments.

Botulinum toxin is a neurotoxin that since 1987 has also been used in aesthetic medicine for the treatment of dynamic wrinkles, i.e. those that are formed due to repeated and concentrated movements in a specific area.

Botulinum toxin, in all its subtypes, is a small protein made up of 2 subparts, one of which is “heavy” and one “light”: the “heavy” polypeptide chain is 100 kDa in weight and is linked by sulphide bridges to the “light” one, which instead is a polypeptide chain of 50 kDa in weight. The action of the botulinum toxin is due to the light chain, which attaches itself to the neuromuscular junction, stopping the release of acetylcholine from the vesicles. It is thanks to the inhibition of the release of acetylcholine that interference with the nerve impulse occurs and therefore muscle relaxation, the ultimate effect of the toxin both in the phenomenon of botulism and in medical and aesthetic uses. Botulinum toxin is “thermolabile”, that is easily degradable by heat: for this reason the preservation of foods that may contain it takes place through an initial cooking step.

Difference between botulinum toxin and filler

Botulinum toxin, often commonly referred to as “botulinum”, and wrinkles have always been considered a winning combination. In fact, compared to the filler, the Botox is much more suitable for correcting dynamic wrinkles, which involve the muscles, compared to the filler which is instead indicated for static imperfections. Thanks to its easy administration, the Botox solution for wrinkles has now supplanted the forehead lifting treatment, a much more invasive surgery to be performed under anesthesia.